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Bence-jones protein
Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22–24 kDa. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. Bence Jones protein refers to a urinary protein that leaves the solution at approximately 56^oC under particular conditions of ionic strength and pH and returns to the solution on further heating to 100^oC. Bence–Jones protein (free monoclonal light chains or light-chain fragments) is found in the urine of many patients with malignancy of B lymphocytes: it only accumulates in plasma if there is glomerular damage. Bence Jones proteins were identified in urine specimens by immunoelectrophoretic and immunofixation analyses with monospecific anti-κ and anti-λ light-chain antiserum.
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Bence-Jones proteins are free light chains of immunoglobulins – in reality, they can be polyclonal or monoclonal, although the term usually is applied to monoclonal light chains associated with plasma cell dyscrasias (e. As proteínas de Bence Jones são cadeias leves livres (ou seja, fragmentos) de imunoglobulinas monoclonais. Sua presença e quantificação na urina auxilia, principalmente, no diagnóstico do mieloma múltiplo, mas também é utilizado na macroglobulinemia de Waldenstrom, na doença de deposição de cadeia leve idiopática, no linfoma de linfócitos B e na amiloidose primária (AL). 31082079 Bookshelf ID: NBK541035 Excerpt Bence Jones protein refers to a urinary protein that leaves the solution at approximately 56^oC under particular conditions of ionic strength and pH and returns to the solution on further heating to 100^oC. 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